Bestseller
Age Defense Retinol Serum 5x
- Five forms of vitamin A target visible aging
- Smooths fine lines, wrinkles & uneven texture
- Zero retinol irritation, redness or flaking
- Plastic surgeon-formulated for sensitive skin
“Every formula I put my name on solves a real problem I see in my Honolulu clinic. Same standards I hold in surgery. Same level of care I give my own patients.”
Powered by Renara™
Renara is ShimChingMD’s proprietary regenerative complex — the anchoring technology behind every formula in this line.
Renara supports skin renewal, hydration, and a healthier-looking complexion over time. It’s the science Dr. Shim Ching built into every product, and the reason this line performs the way it does.
*Individual results vary.
How it works.
Five forms of vitamin A. Every layer of skin.
Traditional retinol converts through one pathway and irritates as a byproduct. The 5-Form Retinol blend uses HPR, bakuchiol, retinyl palmitate, retinaldehyde, and encapsulated retinol — each one targeting a different depth of skin, from epidermis to deep dermis. The result is clinical-strength resurfacing and collagen support without the flaking, redness, or purging that drives most people to quit.
Proven Benefits of 5-Form Retinol
Traditional retinol irritates because it converts through a single pathway. Dr. Ching's clinical blend of five complementary forms of vitamin A — HPR, bakuchiol, retinyl palmitate, retinaldehyde, and encapsulated retinol — delivers the smoothing, resurfacing, and collagen-supporting benefits of prescription-strength retinoids without the flaking, redness, or purging that drives most people to quit.
- Reduces the appearance of fine lines and wrinkles
- Smooths texture and refines pore appearance
- Supports collagen and elastin production
- Strengthens the skin barrier against photodamage
The actives behind the formula.
HPR, bakuchiol, retinyl palmitate, and niacinamide — engineered as a complementary 5-form blend that delivers prescription-strength results without prescription-strength irritation.
HPR (Hydroxypinacolone Retinoate)
Next-generation retinoid, eight times more effective than traditional retinol, without the irritation
Bakuchiol
Plant-based retinol alternative that calms while it resurfaces
Retinyl Palmitate
Gentle vitamin A ester that releases slowly for continuous overnight renewal
Niacinamide
Multi-functional nutrient that brightens tone, strengthens barrier, and balances oil
Visible Results

Simple to add to your routine.
Apply 2-3 drops to clean, dry skin in the evening. Follow with moisturizer. Start 2-3 nights per week and build up. Always wear SPF the following day. Avoid the eye area.
PM · 3-7 nights per weekFrequently asked.
How is this different from traditional retinol?
Will I experience purging or flaking?
How long until I see results?
Can I use this with Vitamin C?
Is this safe for sensitive skin?
How long does one bottle last?