Age Defense Retinol Serum 5XAge Defense Retinol Serum 5XAge Defense Retinol Serum 5XShimChingMD Age Defense Retinol Serum 5X
All-trans retinol
5XAll-trans retinol
MDSurgeon formulated
90Day money-back
USPatented delivery

Age Defense Retinol Serum 5X · Nightly · Surgeon-formulated

The retinol a surgeon reaches for. Softer-looking lines, night after night.

All-trans retinol paired with bakuchiol and licorice root in a patented delivery system, formulated for nightly use without the usual retinol drama. Two to three drops. Then sleep.

30 mL / 1 fl oz · 2–3 months · Fragrance-free

  • Visibly softens the look of fine lines, especially around the mouth
  • Smoother-looking texture and refined-looking pores
  • The look of firmer, more even skin with consistent use
  • Bakuchiol-buffered so sensitive skin can build up gradually
$169

Free US shipping on $150+ · 90-day money-back guarantee

Ships in 1–2 business daysDelivery in 2–8 business days

Complete the routine.Added to your cart with one tap.
Hydra Repair Cream · $119
Seals the serum in on retinol nights
Sunshield Mineral SPF 50 Sunscreen · $49
All-mineral SPF 50 for the morning after
Dr. Shim Ching
Most retinol products are abandoned in week two. This one is built to be kept: all-trans retinol, buffered with bakuchiol, in a delivery system I patented so it works without the flaking.
Dr. Shim Ching, MD, FACS, FRCSC · Double board-certified plastic surgeon, Honolulu

As seen in

Key actives

What is in it, and why.

Every active is here for a reason you can read. Full INCI below.

What is in it, and why.
All-trans retinolBakuchiolPatented delivery

All-trans retinolThe active

The form of vitamin A skin recognizes directly. Supports the look of smoother texture and softer fine lines with consistent nightly use.

Studied in the published formulation.

BakuchiolPlant-derived buffer

Pairs with retinol to keep the formula comfortable, so you can build up to nightly use rather than quitting in week two.

Licorice root extractBotanical

Helps support a more even-looking tone alongside the retinol.

Caffeine + botanical polyphenolsAntioxidants

Soothe the look of redness and help defend against environmental stressors.

Renara™Proprietary recovery complex

ShimChingMD's proprietary recovery complex, the anchoring technology behind every formula in the line. Supports hydration and a healthier-looking complexion over time.

In every ShimChingMD formula
Full ingredient list

Isopentyldiol, Dimethyl Isosorbide, Polysorbate 80, Ethoxydiglycol, Caffeine, Camellia Sinensis Polyphenols, Bakuchiol, Retinol, Purified Water, Glycyrrhiza Glabra (Licorice) Root Extract, Camellia Sinensis Leaf Extract, Glycerin, Polysorbate 20.

The evidence

Surgeon-formulated. Patented formula.

Not a marketing retinol. The formulation behind this serum was studied and published, and the delivery system is patented.

5X Retinol strength tier in the ShimChingMD lineAge Defense Retinol Serum 5X
8wk Judge the look of texture and fine lines in the same bathroom lightConsistent nightly use
90d Money-back guarantee if your skin does not look betterEmail hello@shimchingmd.com for a refund

Draelos ZD, Peterson RS. J Drugs Dermatol. 2020;19(6):625–631. Patented formula US12226510B2. Appearance benefits only; individual results vary.

  • Softens the look of fine lines and wrinkles
  • Smoother-looking texture and refined-looking pores
  • The look of firmer skin
  • A more even, resilient-looking complexion
Dr. Shim Ching, MD, FRCSC, FACS

From Dr. Ching

Every formula I put my name on solves a real problem I see in my Honolulu clinic. This one solves the retinol that people buy and never finish.

Same standards I hold in surgery. Same level of care I give my own patients.

Dr. Shim Ching, MD, FRCSC, FACSDouble board-certified plastic surgeon · Honolulu

How to use

Where it goes in the routine.

☼Morning

Protect.

1
Cleanse
Papaya Enzyme Gentle Cleanser or Recovery Gel Cleanser.Shop →
2
Vitamin C
Three to four drops of Vitamin C + Radiance Serum.Shop →
3
SPF
Sunshield Mineral SPF 50, every morning, especially on retinol weeks.Shop →
☾Night

Unwind.

1
Cleanse
Clean, dry skin. Wait a minute.
2
Age Defense Retinol Serum 5X
Two to three drops. Start two to three nights a week and build up. Avoid the eye area.
3
Moisturize
Hydra Repair Cream to seal it in.Shop →
3–7 nights a weekStart 2–3 nightsAlways SPF next morning

Mild tingling in the first weeks is normal. If skin feels hot or irritated, step back to two nights a week.

Pairs with

Build the routine around it.

ShimChingMD Hydra Repair Cream
Night · Step 3

Hydra Repair Cream

Seals the serum in. Ceramides, cholesterol and squalane for retinol weeks.

$119
ShimChingMD Vitamin C + Radiance Serum
Morning · Step 2

Vitamin C + Radiance Serum

Vitamin C in the morning; retinol stays at night.

$189
ShimChingMD Sunshield Mineral SPF 50 Sunscreen
Morning · Step 3

Sunshield Mineral SPF 50 Sunscreen

All-mineral SPF 50, sheer finish. Non-negotiable on retinol.

$49
L
Lisa
Did you use this after a procedure or treatment?: No

I have received the age defense serum from ShimChingMD for free. I am so satisfied with this serum. The transformation on my skin in the 2 weeks using this product is amazing. My skin looks brighter and so much smoother. I will continue using it.

90-day money-backUse it. If your skin does not look better, email hello@shimchingmd.com for a refund.
Free US shipping on $150+Ships in 1–2 business days, delivered in 2–8.
Formulated by a surgeonDr. Shim Ching, double board-certified plastic surgeon, Honolulu.
Clean by designFragrance-free, paraben-free, cruelty-free.

Reviews

From people who use it.

Questions

Asked before buying.

How is this different from a drugstore retinol?

It uses all-trans retinol, the form skin recognizes directly, buffered with bakuchiol and delivered through a patented system (US12226510B2) that was studied and published. The goal is a retinol you keep using, not one you abandon in week two.

Will I purge or flake?

Some tingling or light dryness in the first two to three weeks is normal. Start two to three nights a week, use a moisturizer over it, and build up. If skin feels hot or irritated, step back.

Can I use it with vitamin C?

Yes. Vitamin C in the morning, retinol at night. They complement each other.

Is it okay for sensitive skin?

The formula pairs retinol with bakuchiol specifically to keep it comfortable. Start slowly, two nights a week, and patch-test if you are reactive.

How long does a bottle last?

Two to three drops nightly from a 30 mL bottle lasts about two to three months.

What about pregnancy?

Retinol is generally not recommended during pregnancy or nursing. Ask your physician.

Individual results vary. Appearance benefits only. This product is not intended to diagnose, treat, cure or prevent any disease.